Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Acetamido-4-chloromethylthiazole → 7-((2-Acetamidothiazol-4-yl)methoxy)4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Acetamido-4-chloromethylthiazole | HCID 81963 | — |
| 반응물 | 4-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride | HCID 135671179 | — |
| 생성물 | 7-((2-Acetamidothiazol-4-yl)methoxy)4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline | HCID 15886046 | 25.2% |
반응 단계
Using an analogous procedure to that described in Example 27, 4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride (470 mg 1.14 mmol), (prepared as described for the starting material in Example 22), and 2-acetamido-4-chloromethylthiazole (381 mg, 1.68 mmol) were combined to give 7-((2-acetamidothiazol-4-yl)methoxy)-4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline (135 mg, 25%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06362336B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-7198824a60df458f987d79be9057038c |
| 출처 메모 | uspto-grants-2002_03 |