Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 2-(Chloromethyl)-1-methylbenzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | (1-methyl-1H-1,3-benzodiazol-2-yl)methanol | HCID 344177 | — |
| 생성물 | 2-(Chloromethyl)-1-methylbenzimidazole | HCID 248044 | 36% |
반응 단계
A solution of 2-hydroxymethyl-1-methylbenzimidazole (1.1 g, 6.7 mmol) in thionyl chloride (10 ml) was stirred at ambient temperature for 15 minutes and then heated at reflux for 15 minutes. The volatiles were removed by evaporation and the residue purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 2-chloromethyl-1-methylbenzimidazole (506 mg, 36%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06362336B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-d8c3115e42f34c5791ca6054fb4ab195 |
| 출처 메모 | uspto-grants-2002_03 |