Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propionic Acid → 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propionic Acid | HCID 1032 | — |
| 반응물 | Propionamide | HCID 6578 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-Chloro-2,4-pentanedione | HCID 74328 | — |
| 생성물 | 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone | HCID 18936328 | — |
반응 단계
3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05731335 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-eb5bfefcbfd94ea0be77c604cb53b9bd |
| 출처 메모 | uspto-grants-1998_03 |