Thionyl Chloride → 4-(Chloromethyl)picolinonitrile hydrochloride
반응식
[C:1]([C:3]1[CH:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][N:4]=1)#[N:2].S(Cl)([Cl:13])=O>C1(C)C=CC=CC=1>[ClH:13].[Cl:13][CH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([C:1]#[N:2])[CH:8]=1참가 물질
4
실험 절차
A mixture of 2-cyano-4-hydroxymethylpyridine (0.51 g, 3.8 mmol) and thionyl chloride (0.6 ml) in toluene (20 ml) was stirred at room temperature for 1 hour. The volatiles were removed by evaporation and the residue azeotroped with toluene to give 4-chloromethyl-2-cyanopyridine hydrochloride (620 mg, 86%).
후처리
- customThe volatiles were removed by evaporation
- customthe residue azeotroped with toluene
출처 및 근거
- ORD 기록
- ord-ceac2a3b37584987bdcf9123d5f184a5
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06362336B1
반응 노트
불러오는 중…