Water → (2-Methoxypyridin-4-yl)methanol
반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9](OCC)=[O:10])[CH:6]=[CH:5][N:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>CCOCC>[OH:10][CH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1참가 물질
5
반응 조건
- 온도
- 5 °C
실험 절차
A solution of ethyl 2-methoxy-pyridine-4-carboxylate (0.93 g, 5 mmol) in ether (5 ml) was added to lithium aluminium hydride (0.3 g, 8 mmol) in ether (10 ml) cooled to 5° C. and the mixture stirred for 2 hours. Water was added, the mixture was filtered through diatomaceous earth and the pad was washed through with ethyl acetate. The filtrate was extracted with ethyl acetate and the combined extracts were washed with brine, dried (MgSO4) and the solvent removed by evaporation to give 4-hydroxymethyl-2-methoxypyridine (0.64 g, 89%) as a yellow oil.
후처리
- filtrationthe mixture was filtered through diatomaceous earth
- washthe pad was washed through with ethyl acetate
- extractionThe filtrate was extracted with ethyl acetate
- washthe combined extracts were washed with brine
- dry with materialdried (MgSO4)
- customthe solvent removed by evaporation
출처 및 근거
- ORD 기록
- ord-bf3e814d5f194dafbe6d0d4077f16d0c
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06362336B1
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