Water → (2-Methylpyridin-4-yl)methanol

HRID 279612

반응식

HRID 279612 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](OC)=[O:9])[CH:5]=[CH:4][N:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>CCOCC>[OH:9][CH2:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 11542811Methyl 2-methylisonicotinateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 9942144(2-Methylpyridin-4-yl)methanol수율 38%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
5 °C

실험 절차

A solution of methyl 2-methyl-pyridine-4-carboxylate (800 mg, 6 mmol) in ether (5 ml) was added to lithium aluminium hydride (340 mg, 9mmol) in ether (10 ml) cooled to 5° C. and the mixture stirred for 2 hours. Water was added, the mixture was filtered through diatomaceous earth and the pad was washed through with ethyl acetate. The filtrate was extracted with ethyl acetate and the combined extracts were washed with brine, dried (MgSO4) and the solvent removed by evaporation to give 4-hydroxymethyl-2-methylpyridine (240 mg, 38%) as a yellow oil.

후처리

  1. filtrationthe mixture was filtered through diatomaceous earth
  2. washthe pad was washed through with ethyl acetate
  3. extractionThe filtrate was extracted with ethyl acetate
  4. washthe combined extracts were washed with brine
  5. dry with materialdried (MgSO4)
  6. customthe solvent removed by evaporation

출처 및 근거

ORD 기록
ord-b0a10f74ee6e4ac7b5572d06957e5e55
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362336B1

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