Dimethylformamide → HCID 14456868, 화합물

HRID 279782노트

반응식

HRID 279782 반응식
[CH3:1][O:2][C:3]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:4]=1[CH2:5][N:6]1[CH:9]([CH2:10]I)[CH2:8][C:7]1=[O:12].[CH3:19][N:20](C)C=O.[C-]#N.[Na+]>O>[C:19]([CH2:10][CH:9]1[N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:3]=2[O:2][CH3:1])[C:7](=[O:12])[CH2:8]1)#[N:20]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 14456867HCID 14456867, 화합물

생성물 1

HCID 14456868HCID 14456868, 화합물수율 70%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 1.2 g (3.3 millimoles) of 1-(2,4-dimethoxy-benzyl)-4-iodomethyl-2-azetidinone and 5 ml of dimethyl formamide is stirred with 0.35 g (7 millimoles) of sodium cyanide at room temperature for 48 hours. The solution is poured onto 30 ml of water and extracted five times with 20 ml of ether each. The etheral solution is dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated in vacuo. Thus 0.6 g of 4-cyanomethyl-1-(2,4-dimethoxy-benzyl)-2-azetidinone are obtained. Yield: 70%.

후처리

  1. extractionextracted five times with 20 ml of ether each
  2. dry with materialThe etheral solution is dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customthe filtrate is evaporated in vacuo

출처 및 근거

ORD 기록
ord-7f060409e59a45c5ae2a43fc44b3b30b
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587049

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