Sodium Methoxide → Ethyl cyanoacrylate

HRID 279789

반응식

HRID 279789 반응식
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:15]#[N:16])[CH2:6]C(C#N)C(OCC)=O)[CH3:2].C[O-].[Na+].C(OC(=O)CCCC(OC#N)=O)#N>CO.O>[CH2:1]([O:3][C:4](=[O:17])[C:5]([C:15]#[N:16])=[CH2:6])[CH3:2]

참가 물질

7

반응물 4

HCID 10942334Sodium Methoxide2회HCID 15932776Diethyl 2,4-dicyanopentanedioateHCID 86740765DicyanoglutarateHCID 178486302HCID 178486302, 화합물

생성물 1

HCID 81530Ethyl cyanoacrylate수율 59.6%

시약·촉매·용매 2

HCID 887Methanol촉매HCID 962Water용매

실험 절차

494.0 g (2.074 moles) of 2,4-dicyanoglutaric acid diethyl ester were reacted in the absence of water with 44.8 g of polyoxymethylene (92%; 1.372 moles) and 3 g of a 30% solution of sodium methylate in methanol (0.0167 mole). The quantity of sodium methylate used corresponded to an excess of 1.25 millimoles per mole of dicyanoglutarate. The reaction was carried out over a period of 45 minutes at a temperature of 100° C.-130° C. The water present was then removed using an oil pump vacuum. Thermolysis produced 154.5 g (1.236 moles) of 2-cyanoacrylic acid ethyl ester after distillation. The yield thus amounted to 31.3% by weight, based on 2,4-dicyanoglutarate.

후처리

  1. customThe water present was then removed

출처 및 근거

ORD 기록
ord-ac7b614eb6fb42a09e49033fdddffcb0
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587059

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