Chlorotrimethylsilane → 4-Methyl-2-trimethylsilylthiazole

HRID 2798

반응식

HRID 2798 반응식
C([Li])CCC.[CH3:6][C:7]1[N:8]=[CH:9][S:10][CH:11]=1.[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>C(OCC)C>[CH3:6][C:7]1[N:8]=[C:9]([Si:13]([CH3:15])([CH3:14])[CH3:12])[S:10][CH:11]=1

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 127484-MethylthiazoleHCID 178418339Butyllithium

생성물 1

HCID 116583544-Methyl-2-trimethylsilylthiazole

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

n-Butyllithium (2.5M solution in hexane, 1.1 equivalents) was added dropwise to a solution of 4-methylthiazole (1.0 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, trimethylsilylchloride (1.0 equivalent) was added dropwise. The mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work-up in the normal fashion and vacuum distillation then gave the title compound. B.p. 42° C. at 1 mmHg.

후처리

  1. customwas then quenched by the addition of saturated aqueous sodium hydrogen carbonate
  2. distillationWork-up in the normal fashion and vacuum distillation

출처 및 근거

ORD 기록
ord-5a7b382c7d5a4739a7806a3eb2f4a308
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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