Chlorotrimethylsilane → 4-Methyl-2-trimethylsilylthiazole
반응식
C([Li])CCC.[CH3:6][C:7]1[N:8]=[CH:9][S:10][CH:11]=1.[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>C(OCC)C>[CH3:6][C:7]1[N:8]=[C:9]([Si:13]([CH3:15])([CH3:14])[CH3:12])[S:10][CH:11]=1참가 물질
5
실험 절차
n-Butyllithium (2.5M solution in hexane, 1.1 equivalents) was added dropwise to a solution of 4-methylthiazole (1.0 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, trimethylsilylchloride (1.0 equivalent) was added dropwise. The mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work-up in the normal fashion and vacuum distillation then gave the title compound. B.p. 42° C. at 1 mmHg.
후처리
- customwas then quenched by the addition of saturated aqueous sodium hydrogen carbonate
- distillationWork-up in the normal fashion and vacuum distillation
출처 및 근거
- ORD 기록
- ord-5a7b382c7d5a4739a7806a3eb2f4a308
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05731335
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