Phenylurea → p-Nitrophenyl phenylcarbamoylcarbamate

HRID 27992

반응식

HRID 27992 반응식
[C:1]1([NH:7][C:8]([NH2:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:13]>C1COCC1>[C:1]1([NH:7][C:8]([NH:10][C:12](=[O:13])[O:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 6145PhenylureaHCID 821294-Nitrophenyl chloroformate

생성물 1

HCID 13097706p-Nitrophenyl phenylcarbamoylcarbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 6.8 g. of phenylurea in 50 ml. of dry THF maintained at 0° C. under nitrogen were added 5.05 g. of p-nitrophenyl chloroformate. The reaction mixture was allowed to warm to room temperture and was stirred for about 18 hours. The mixture was evaporated to dryness and the residue dissolved in ethyl acetate. The solution was washed twice with water, twice with brine, and was filtered through sodium sulfate. The filtrate was evaporated to dryness to yield 4.9 g. of the product as a white product.

후처리

  1. additionwere added 5.05 g
  2. temperatureto warm to room temperture
  3. customThe mixture was evaporated to dryness
  4. dissolutionthe residue dissolved in ethyl acetate
  5. washThe solution was washed twice with water, twice with brine
  6. filtrationwas filtered through sodium sulfate
  7. customThe filtrate was evaporated to dryness
  8. customto yield 4.9 g

출처 및 근거

ORD 기록
ord-f7c73e145846469f815f3d2c37bfe350
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04224442

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