Sodium Methoxide → 7-Bromo-2-methoxy-4-methylquinoline

HRID 280000노트

반응식

HRID 280000 반응식
Cl[C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([Br:13])=[CH:7][CH:8]=2)[N:3]=1.[CH3:14][O-:15].[Na+]>CO>[CH3:14][O:15][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([Br:13])=[CH:7][CH:8]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 145703037-Bromo-2-chloro-4-methylquinoline

생성물 1

HCID 145703057-Bromo-2-methoxy-4-methylquinoline수율 89.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 3.00 g (12.00 mM) of 2-chloro-4-methyl-7-bromoquinoline and 0.63 g (12.00 mM) of sodium methoxide was heated to reflux in 30 mL of dry methanol for 48 h. The methanol was then removed in vacuo, and the resultant concentrate was taken up in methylene chloride. This methylene chloride solution was washed repeatedly with saturated sodium chloride. After drying (MgSO4), solvent removal, and recrystallisation from toluene, 2.63 g (87%) of the product was obtained as white crystals: mp 58°-60° C.

후처리

  1. temperaturewas heated
  2. customThe methanol was then removed in vacuo
  3. concentrationthe resultant concentrate
  4. washThis methylene chloride solution was washed repeatedly with saturated sodium chloride
  5. customAfter drying
  6. custom(MgSO4), solvent removal, and recrystallisation from toluene

출처 및 근거

ORD 기록
ord-472bb6864b6445498dd82e522fb16917
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587341

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