Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1,1-Trifluoro-2,4-pentanedione → 1-(2-Amino-4-(trifluoromethyl)thiazol-5-yl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1,1-Trifluoro-2,4-pentanedione | HCID 73943 | — |
| 반응물 | Thiourea | HCID 2723790 | — |
| 반응물 | Hydroxy tosyloxy iodobenzene | HCID 21918218 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(2-Amino-4-(trifluoromethyl)thiazol-5-yl)ethanone | HCID 18936300 | — |
반응 단계
Hydroxy(tosyloxy)iodobenzene (78.5 g) was added to a solution of 1,1,1-trifluoropentane-2,4-dione in acetonitrile (500 ml). The mixture was heated under reflux for 45 minutes, then cooled, and thiourea (15.2 g) was added. The mixture was heated under reflux for 4 hours and then left to stand overnight. Evaporation and crystallisation of the residue from dichloromethane gave the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05731335 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-ea8d9c1fc5de4b569364ab4d8c41abcc |
| 출처 메모 | uspto-grants-1998_03 |