HCID 178487720, 화합물 → Isoxazolo(4,5-c)quinolin-3(2H)-one, 7-methoxy-2-phenyl-
반응식
O[N:2]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:3]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([O:16][CH3:17])[CH:9]=2)=[O:4]>O>[CH3:17][O:16][C:10]1[CH:11]=[CH:12][C:13]2[C:14]3[O:15][N:2]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C:3](=[O:4])[C:5]=3[CH:6]=[N:7][C:8]=2[CH:9]=1참가 물질
3
실험 절차
Using the procedure of Step B of Example 2, 3.68 g of N,4-dihydroxy-7-methoxy-N-phenyl-3-quinoline carboxamide were reacted and after 18 hours at ambient temperature, the reaction mixture was poured into water and the products which crystallized were extracted with dichloromethane. The organic phase was washed with water and the solvent was eliminated. The residue was chromatographed on silica and eluted with a mixture of methylene chloride-ethyl acetate (9-1) to obtain 0.7 g of 7-methoxy-2-phenylisoxazolo(4,5-c)quinolin-3-(2H)-one melting at 170° C.
후처리
- customwere reacted and after 18 hours at ambient temperature