Methylamine → 1-Amino-2-(2-fluorobenzoyl)pyrrole
반응식
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[C:4]([C:6]1[N:7]([N:11]2C(=O)C3=CC=CC=C3C2=O)[CH:8]=[CH:9][CH:10]=1)=[O:5].CN>CN(C=O)C.O>[NH2:11][N:7]1[CH:8]=[CH:9][CH:10]=[C:6]1[C:4](=[O:5])[C:3]1[CH:22]=[CH:23][CH:24]=[CH:25][C:2]=1[F:1]참가 물질
5
실험 절차
To a suspension of 2-(2-fluorobenzoyl)-1-phthalimidopyrrole (12.5 g, 27 mmole) in 40 ml DMF was added 40 ml methylamine (40% solution in water). After stirring one hour at ambient temperature, the reaction mixture was diluted with water and extracted with ether. The organic extract was washed with water and with saturated NaCl solution, dried over anhydrous MgSO4, filtered and evaporated to 9 L g oil, half of which was purified by Kugelrohr distillation (120°-130° at 0.2 mm Hg) to give 3.5 g (93%) solid, m.p. 44°-47°.
후처리
- extractionextracted with ether
- extractionThe organic extract
- washwas washed with water and with saturated NaCl solution
- dry with materialdried over anhydrous MgSO4
- filtrationfiltered
- customevaporated to 9 L g oil, half of which
- distillationwas purified by Kugelrohr distillation (120°-130° at 0.2 mm Hg)
출처 및 근거
- ORD 기록
- ord-dc1a0d691de7435da2494afb2f5a93d6
- 출처 데이터셋
- uspto-grants-1986_05
- 특허 번호
- US04588727
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