Water → HCID 178487220, 화합물

HRID 280161노트

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HRID 280161 반응식
[C:1]([CH:3]1[C:6]2=[CH:7][C:8]([O:11][CH3:12])=[CH:9][CH:10]=[C:5]2[CH2:4]1)#N.[OH-:13].[K+].[OH2:15]>C(O)C.CCOCC>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]2[CH:4]=[C:3]([C:1]([OH:15])=[O:13])[C:6]=2[CH:7]=1

참가 물질

6

반응물 3

HCID 962Water2회HCID 14797Potassium HydroxideHCID 12238660Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-methoxy-

생성물 1

HCID 178487220HCID 178487220, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3283Diethyl Ether용매

실험 절차

1-Cyano-5-methoxybenzocyclobutene (29 g) is stirred with saturated KOH in ethanol (180 ml) for about 12 hours under nitrogen at RT. Water (60 ml) is added to the reaction mixture which is refluxed for about 3 hours. The mixture is cooled to RT, diluted with water, washed with ether and the aqueous layer acidified forming an oil. The oil is dissolved in ether and the ethereal solution washed, dried over Na2SO4, filtered and evaporated in vacuo affording the desired product as an oil.

후처리

  1. temperatureis refluxed for about 3 hours
  2. washwashed with ether
  3. customthe aqueous layer acidified forming an oil
  4. washthe ethereal solution washed
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-0d2bf00a0ce748859ba871c82926861f
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588719

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