1,8-Diazabicyclo(5.4.0)undec-7-ene → 4H-Pyrano(2,3-b)pyridine, 6-bromo-2-(3,4-dichlorophenyl)-

HRID 280192노트

반응식

HRID 280192 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[CH:11]=[CH:10][CH:9]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=3)[O:8][C:5]2=[N:6][CH:7]=1.N12CCCN=C1CCCCC2>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]2[CH2:11][CH:10]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=3)[O:8][C:5]2=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 5149096-bromo-2-(3,4-dichlorophenyl)-2H-pyrano[2,3-b]pyridine

생성물 1

HCID 5149104H-Pyrano(2,3-b)pyridine, 6-bromo-2-(3,4-dichlorophenyl)-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2.9 g of 6-bromo-2-(3,4-dichlorophenyl)-2H-pyrano[2,3-b]pyridine in 40 ml of tetrahydrofuran was added 0.5 ml of 1,8-diazabicyclo[5.4.0]undec-7-ene. After 1 hour at 25° C., the reaction mixture was partitioned between ethyl acetate and aqueous saturated ammonium chloride solution. The ethyl acetate layer was dried over magnesium sulfate and the solvent was evaporated to leave a solid residue. This was recrystallized from ethanol to give 6-bromo-2-(3,4-dichlorophenyl)-4H-pyrano[2,3-b]pyridine melting at about 138°-139.5° C.

후처리

  1. customthe reaction mixture was partitioned between ethyl acetate and aqueous saturated ammonium chloride solution
  2. dry with materialThe ethyl acetate layer was dried over magnesium sulfate
  3. customthe solvent was evaporated
  4. customto leave a solid residue
  5. customThis was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-eafa897dc1514dfeadaa3a24cf00cebe
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588733

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