Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Benzyloxyphenylacetaldehyde → HCID 23322068, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Benzyloxyphenylacetaldehyde | HCID 11413489 | — |
| 반응물 | 4-(2-Aminoethyl)-1,3-dihydro-2H-indol-2-one | HCID 23322037 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 23322068 | HCID 23322068 | — |
반응 단계
A mixture of 0.9 g of 4-(2-aminoethyl)-2(3H)-indolone, 0.23 g of 4-benzyloxyphenylacetaldehyde, 0.25 g of 10% palladium-on-charcoal and 100 ml of ethanol is hydrogenated at 50 p.s.i. at 50° until the uptake of hydrogen is complete. After filtration, the mother liquors are evaporated to give 4-[2-(4-hydroxyphenethylamino)-ethyl]-2(3H)-indolone as the residue. This base in alcohol is treated with an excess of methanesulfonic acid to give the methanesulfonate salt.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04588740 |
| 출처 데이터셋 | uspto-grants-1986_05 |
| ORD ID | ord-c7c7e9eb37c648118c095d56bb37f520 |
| 출처 메모 | uspto-grants-1986_05 |