Phosphate → 3-Phenylacetamido-4-(2-hydroxyethyl)-2-azetidinone

HRID 28029노트

반응식

HRID 28029 반응식
O1CCCCC1[N:7]1[CH:10]([CH2:11][CH2:12][O:13]C2CCCCO2)[CH:9]([NH:20][C:21](=[O:29])[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:8]1=[O:30].O.C1(C)C=CC(S(O)(=O)=O)=CC=1.P([O-])([O-])([O-])=O>CO>[C:23]1([CH2:22][C:21]([NH:20][CH:9]2[CH:10]([CH2:11][CH2:12][OH:13])[NH:7][C:8]2=[O:30])=[O:29])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

참가 물질

5

반응물 3

HCID 1061PhosphateHCID 521998p-Toluenesulfonic acid monohydrateHCID 541458371-(2-Tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone

생성물 1

HCID 128047363-Phenylacetamido-4-(2-hydroxyethyl)-2-azetidinone

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-(2-tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone in methanol at 25° C. is treated with 0.1 molar equivalent of p-toluenesulfonic acid monohydrate. The solution is stirred for a period of 2 hours and then neutralized with 1 M pH 7 phosphate buffer. The product is extracted into ethyl acetate. The ethyl acetate solution is washed with brine, dried over magnesium sulfate and filtered. The filtrate is evaporated under reduced pressure to give 3-phenylacetamido-4-(2-hydroxyethyl)-2-azetidinone.

후처리

  1. extractionThe product is extracted into ethyl acetate
  2. washThe ethyl acetate solution is washed with brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customThe filtrate is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ea8cdd94150e48d29a1b4c8f95459dc3
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04224336

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