Water → 4-Methyl-2-trifluoroacetyloxazole
반응식
[F:1][C:2]([F:11])([F:10])[C:3](N1C=CN=C1)=[O:4].[CH3:12][C:13]1[N:14]=[C:15]([Si](C)(C)C)[O:16][CH:17]=1.O>C(OCC)C>[CH3:12][C:13]1[N:14]=[C:15]([C:3](=[O:4])[C:2]([F:11])([F:10])[F:1])[O:16][CH:17]=1참가 물질
5
실험 절차
1-Trifluoroacetylimidazole (10 g) was added dropwise to 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. under an atmosphere of dry nitrogen. The mixture was stirred overnight at room temperature. Water was added and the organic layer was separated, washed, dried and evaporated. Flash chromatography gave the title compound.
후처리
- customthe organic layer was separated
- washwashed
- customdried
- customevaporated
출처 및 근거
- ORD 기록
- ord-4117f1caea15466f91091f87c8c7eae4
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05731335
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