Phenylglyoxal → N-(2-(4-Methylphenyl)ethyl)-2-hydroxy-2-phenylethanamine

HRID 280308

반응식

HRID 280308 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH2:10])=[CH:4][CH:3]=1.FC(F)(F)[C:13]1[CH:14]=[C:15]([C:19]([CH:21]=O)=[O:20])[CH:16]=[CH:17][CH:18]=1.C1(C(C=O)=O)C=CC=CC=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH:10][CH2:21][CH:19]([OH:20])[C:15]2[CH:16]=[CH:17][CH:18]=[CH:13][CH:14]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 14090PhenylglyoxalHCID 76751p-MethylphenethylamineHCID 27832843-(Trifluoromethyl)phenylglyoxal

생성물 1

HCID 23322154N-(2-(4-Methylphenyl)ethyl)-2-hydroxy-2-phenylethanamine

실험 절차

The title compound was prepared in the manner described in Example 9, replacing 2-(4-methylphenyl)-1,1-dimethylethanamine by 2-(4-methylphenyl)ethanamine and 3-trifluoromethylphenylglyoxal by phenylglyoxal. The chromatographed material was recrystallised from hexane to give the title compound, mp 95°-97°.

후처리

  1. customThe title compound was prepared in the manner
  2. customThe chromatographed material was recrystallised from hexane

출처 및 근거

ORD 기록
ord-2b3502e5393e4644bdebfb3df05b7ba9
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588749

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