Phenylglyoxal → HCID 23322164, 화합물

HRID 280318노트

반응식

HRID 280318 반응식
[C:1]1([C:7]([CH:9]=O)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[CH2:19][CH:20]([CH3:22])[NH2:21]>>[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[CH2:19][CH:20]([NH:21][CH2:9][CH:7]([OH:8])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:22]

참가 물질

3

반응물 2

HCID 14090PhenylglyoxalHCID 541870α,2,4-Trimethylbenzeneethanamine

생성물 1

HCID 23322164HCID 23322164, 화합물

실험 절차

The title compound was prepared in the manner described in Example 9 using phenylglyoxal and 2-(2,4-dimethylphenyl)-1-methylethanamine. The residual oil was chromatographed on Kieselgel 60 using 3% methanol-chloroform. Recrystallization of the resulting solid from hexane gave the title compound m.p. 91-92 as a 6:94 mixture of diastereoisomers. τ(CDCl3) 8.9 (3H, d, J=6 Hz), 7.7 (6H, s), 6.9-7.6 (5H, (m) +2H, disappears with D2O) 5.35 (1H, m), 3.05 (3H, s), 2.68 (5H, m).

후처리

  1. customThe title compound was prepared in the manner
  2. customThe residual oil was chromatographed on Kieselgel 60 using 3% methanol-chloroform
  3. customRecrystallization of the resulting solid from hexane

출처 및 근거

ORD 기록
ord-33c0f56da80248e6a6139b4be30369e5
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588749

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