Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → p-Methylphenethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | p-Tolylacetonitrile | HCID 76280 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | p-Methylphenethylamine | HCID 76751 | 112.4% |
반응 단계
4-Methylbenzyl cyanide (10 g) in ether was added dropwise under nitrogen to lithium aluminium hydride (2.9 g) in ether. The solution was refluxed for 1 h at the end of addition. The reaction mixture was cooled, water (3 ml), 2N.NaOH (3 ml), and further water (9 ml) were added, the reaction mixture filtered, the residue washed with chloroform and the combined solvents dried (MgSO4). Evaporation gave 2-(4-methylphenyl)ethanamine (11.59 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04588749 |
| 출처 데이터셋 | uspto-grants-1986_05 |
| ORD ID | ord-8d346d46b6794136a0e86b9fa123deeb |
| 출처 메모 | uspto-grants-1986_05 |