Water → p-Methylphenethylamine

HRID 280325

반응식

HRID 280325 반응식
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][C:7]#[N:8])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 76280p-TolylacetonitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 76751p-Methylphenethylamine수율 112.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

4-Methylbenzyl cyanide (10 g) in ether was added dropwise under nitrogen to lithium aluminium hydride (2.9 g) in ether. The solution was refluxed for 1 h at the end of addition. The reaction mixture was cooled, water (3 ml), 2N.NaOH (3 ml), and further water (9 ml) were added, the reaction mixture filtered, the residue washed with chloroform and the combined solvents dried (MgSO4). Evaporation gave 2-(4-methylphenyl)ethanamine (11.59 g).

후처리

  1. temperatureThe solution was refluxed for 1 h at the end of addition
  2. temperatureThe reaction mixture was cooled
  3. filtrationthe reaction mixture filtered
  4. washthe residue washed with chloroform
  5. dry with materialthe combined solvents dried (MgSO4)
  6. customEvaporation

출처 및 근거

ORD 기록
ord-8d346d46b6794136a0e86b9fa123deeb
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588749

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