Sodium Carbonate → N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-propoxyaniline

HRID 28043

반응식

HRID 28043 반응식
[CH2:1]([O:4][C:5]1[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=1[NH2:7])[CH2:2][CH3:3].C(=O)([O-])[O-].[Na+].[Na+].Br[CH2:19][CH:20]1[O:24][CH:23]([CH3:25])[CH:22]([CH3:26])[O:21]1>>[CH3:26][CH:22]1[CH:23]([CH3:25])[O:24][CH:20]([CH2:19][NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[O:4][CH2:1][CH2:2][CH3:3])[O:21]1

참가 물질

4

반응물 3

HCID 10340Sodium CarbonateHCID 21134322-PropoxyanilineHCID 128944572-Bromomethyl-4,5-dimethyl-1,3-dioxolane

생성물 1

HCID 23338379N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-propoxyaniline

실험 절차

2-Propoxyaniline (0.5 mole) and sodium carbonate (30 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4,5-dimethyl-1,3-dioxolane (0.55 mole) is slowly added and the reaction mixture is heated at reflux for a period of about 1 hour. After this time the reaction mixture is filtered and additional sodium carbonate (5 grams) is added to the filtrate. The mixture is then distilled under reduced pressure to yield the desired product N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-propoxyaniline.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperaturethe reaction mixture is heated
  4. temperatureat reflux for a period of about 1 hour
  5. filtrationAfter this time the reaction mixture is filtered
  6. additionadditional sodium carbonate (5 grams) is added to the filtrate
  7. distillationThe mixture is then distilled under reduced pressure

출처 및 근거

ORD 기록
ord-9cc5f3ae89ae4e3899260a2c342215b3
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225335

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