Sodium Carbonate → N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-n-butoxyaniline

HRID 28044

반응식

HRID 28044 반응식
[CH2:1]([O:5][C:6]1[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=1[NH2:8])[CH2:2][CH2:3][CH3:4].C(=O)([O-])[O-].[Na+].[Na+].Br[CH2:20][CH:21]1[O:25][CH:24]([CH3:26])[CH:23]([CH3:27])[O:22]1>>[CH3:27][CH:23]1[CH:24]([CH3:26])[O:25][CH:21]([CH2:20][NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[O:5][CH2:1][CH2:2][CH2:3][CH3:4])[O:22]1

참가 물질

4

반응물 3

HCID 10340Sodium CarbonateHCID 1382652-ButoxyanilineHCID 128944572-Bromomethyl-4,5-dimethyl-1,3-dioxolane

생성물 1

HCID 23338378N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-n-butoxyaniline

반응 조건

온도
100 °C

실험 절차

2-n-Butoxyaniline (99 grams; 0.6 moles) and sodium carbonate (31.6 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4,5-dimethyl-1,3-dioxolane (25 ml) was added and the reaction mixture was heated at a temperature of about 100° C. for a period of about 4 hours. After this time the reaction mixture was filtered and additional sodium carbonate (5.0 grams) was added to the filtrate. The mixture was then vacuum distilled and the fraction boiling at 123° C. and 0.05 mm of Hg pressure was collected to yield the desired product N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-n-butoxyaniline.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. filtrationAfter this time the reaction mixture was filtered
  4. additionadditional sodium carbonate (5.0 grams) was added to the filtrate
  5. distillationvacuum distilled
  6. customthe fraction boiling at 123° C. and 0.05 mm of Hg pressure was collected

출처 및 근거

ORD 기록
ord-0eabac01f602400795b8517efba6e5fe
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225335

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