Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 1-Ethyl-1-azabicyclo[2.2.2]octan-1-ium iodide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | Quinuclidine | HCID 7527 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-Ethyl-1-azabicyclo[2.2.2]octan-1-ium iodide | HCID 13652287 | — |
반응 단계
20 grams of Quinuclidine (1 Aza bicyclo [2.2.2]octane, Aldrich) were dissolved in 100 ml of chloroform with stirring and cooling in an ice bath. 28.08 Grams of ethyl iodide (Aldrich) were added dropwise. The mixture became cloudy and was stirred overnight, slowly coming to room temperature. Acetone was added to the solution and then, with stirring, diethyl ether was added dropwise until crystals formed. The filtered solids were washed with acetone and dried under vacuum. The product had the correct microanalysis for C, H, and N.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04589977 |
| 출처 데이터셋 | uspto-grants-1986_05 |
| ORD ID | ord-18eefcdd3d8042688da2c968be430e09 |
| 출처 메모 | uspto-grants-1986_05 |