Acetone → 1-Ethyl-1-azabicyclo[2.2.2]octan-1-ium iodide

HRID 280479

반응식

HRID 280479 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[CH2:9]([I:11])[CH3:10].CC(C)=O.C(OCC)C>C(Cl)(Cl)Cl>[I-:11].[CH2:9]([N+:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2)[CH3:10]

참가 물질

6

반응물 4

HCID 180AcetoneHCID 3283Diethyl EtherHCID 6340IodoethaneHCID 7527Quinuclidine

생성물 1

HCID 136522871-Ethyl-1-azabicyclo[2.2.2]octan-1-ium iodide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

20 grams of Quinuclidine (1 Aza bicyclo [2.2.2]octane, Aldrich) were dissolved in 100 ml of chloroform with stirring and cooling in an ice bath. 28.08 Grams of ethyl iodide (Aldrich) were added dropwise. The mixture became cloudy and was stirred overnight, slowly coming to room temperature. Acetone was added to the solution and then, with stirring, diethyl ether was added dropwise until crystals formed. The filtered solids were washed with acetone and dried under vacuum. The product had the correct microanalysis for C, H, and N.

후처리

  1. temperaturecooling in an ice bath
  2. stirringwas stirred overnight
  3. customslowly coming to room temperature
  4. stirringwith stirring
  5. customformed
  6. washThe filtered solids were washed with acetone
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-18eefcdd3d8042688da2c968be430e09
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04589977

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