Water → 1-(4-Methyl-5-oxazolyl)-1-(3-thienyl)ethanol

HRID 2806

반응식

HRID 2806 반응식
Br[C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.C([Li])CCC.[C:12]([C:15]1[O:19][CH:18]=[N:17][C:16]=1[CH3:20])(=[O:14])[CH3:13].O>C(OCC)C>[CH3:20][C:16]1[N:17]=[CH:18][O:19][C:15]=1[C:12]([C:2]1[CH:6]=[CH:5][S:4][CH:3]=1)([OH:14])[CH3:13]

참가 물질

6

반응물 4

HCID 962WaterHCID 133833-BromothiopheneHCID 110298391-(4-Methyloxazol-5-yl)ethanoneHCID 178418339Butyllithium

생성물 1

HCID 189363241-(4-Methyl-5-oxazolyl)-1-(3-thienyl)ethanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

실험 절차

3-Bromothiophene (4.23 g) in diethylether (10 ml) was added dropwise to n-butyllithium (2.5M solution in hexane, 10.4 ml) in dry diethylether (20 ml) at -70° C. under a nitrogen atmosphere. After 3 hours 5-acetyl-4-methyloxazole (2.5 g) in diethylether (10 ml) was added dropwise. After a further 2.5 hours at -70° C., the mixture was allowed to warm to room temperature and then left overnight. The mixture was poured into water and extracted with ether. The product thus obtained was crystallised from diethylether to give 1-(4-methyl-5-oxazolyl)-1-(3-thienyl)ethanol, m.p. 87°-89° C.

후처리

  1. waitleft overnight
  2. extractionextracted with ether
  3. customThe product thus obtained
  4. customwas crystallised from diethylether

출처 및 근거

ORD 기록
ord-4d4da764b7ca493a80454e012df84e7d
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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