Water → 5-Bromo-3-ethyl-1-benzofuran-2-carboxylic acid

HRID 280625노트

반응식

HRID 280625 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]#N)=[C:7]([CH2:12][CH3:13])[C:6]=2[CH:14]=1.[OH-:15].[K+].[OH2:17]>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([OH:17])=[O:15])=[C:7]([CH2:12][CH3:13])[C:6]=2[CH:14]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 23320940HCID 23320940, 화합물

생성물 1

HCID 233208915-Bromo-3-ethyl-1-benzofuran-2-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 5-bromo-3-ethylbenzofuran-2-carbonitrile (2.00 g), potassium hydroxide (1.00 g), water (10 ml) and ethanol (0.5 ml) was heated under reflux for 48 hours and then the solvent was evaporated. The residue was dissolved in water and the solution was filtered and acidified with 2N hydrochloric acid. The solid was filtered off, washed with water and dried to give 5-bromo-3-ethylbenzofuran-2-carboxylic acid (2.01 g) which had m.p. 240°-242° after crystallisation from methanol/H2O.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customthe solvent was evaporated
  4. dissolutionThe residue was dissolved in water
  5. filtrationthe solution was filtered
  6. filtrationThe solid was filtered off
  7. washwashed with water
  8. customdried

출처 및 근거

ORD 기록
ord-2f8a87956d3b4e709236744aa13c0038
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04590200

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