3-Anilinopropionitrile → 3-Anilino-2-(5-methoxy-1-methyl-3-indolylmethyl)acrylonitrile

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[CH:7]=[C:6]2[CH:13]=O.[NH:15]([CH2:22][CH2:23][C:24]#[N:25])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[NH:15]([CH:22]=[C:23]([CH2:13][C:6]1[C:5]2[C:9](=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[CH:4]=2)[N:8]([CH3:12])[CH:7]=1)[C:24]#[N:25])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

반응물 2

HCID 141003-Anilinopropionitrile

HCID 9259735-methoxy-1-methyl-1H-indole-3-carbaldehyde

생성물 1

HCID 679370733-Anilino-2-(5-methoxy-1-methyl-3-indolylmethyl)acrylonitrile

실험 절차

The title compound was prepared from 5-methoxy-1-methylindole-3-carboxaldehyde (S. Misztal, Dessert. Pharm. Pharmacol., 1972, 24, 509) and 3-anilinopropionitrile by the procedure of Example 4A (71%); the structure was confirmed by 1H-NMR.

출처 및 근거

ORD 기록: ord-e4a7fa38c261430191bbf993e2ebe593
출처 데이터셋: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04590271

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