Ethyl butyrimidate → HCID 178512693, 화합물

HRID 280738

반응식

HRID 280738 반응식
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10](NN)=[O:11])[N:9]=1)[C:2]([NH2:4])=[NH:3].C(=N)([O:18]CC)CCC.Cl.C(OC(=N)CCC)C>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]([OH:11])=[O:18])[N:9]=1)[C:2]([NH2:4])=[NH:3]

참가 물질

5

반응물 3

HCID 16634Ethyl butyrimidateHCID 12235055Ethyl butyrimidate hydrochlorideHCID 178512692HCID 178512692, 화합물

생성물 1

HCID 178512693HCID 178512693, 화합물수율 78%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.90 g (14.48 mol) of 2-guanidino-4-thiazole carboxylic acid hydrazide in 50 ml dry ethanol was slurried with 29.1 mmol of ethyl butyrimidate (prepared from 4.41 g (29.1 mmol) of ethylbutyrimidate hydrochloride) for 5 days at 25°. The slurry was filtered and washed with ethanol and ether and dried to give 3.071 g (78%) of 2-guanidino-4-thiazole carboxylic acid 2-butyriminohydrazide.

후처리

  1. filtrationThe slurry was filtered
  2. washwashed with ethanol and ether
  3. customdried

출처 및 근거

ORD 기록
ord-0ecb7b16d9c74f0583292ff94edb421e
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04590299

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