HCID 178419747, 화합물 → HCID 178419718, 화합물

HRID 280743

반응식

HRID 280743 반응식
Br.[Br:2][CH2:3][C:4]([C:6]([C:8]1[N:9]=[CH:10][NH:11][CH:12]=1)=[O:7])=O.[C:13]([NH:16][C:17]([NH2:19])=[S:18])(=[NH:15])[NH2:14]>CC(C)=O>[BrH:2].[NH:16]([C:17]1[S:18][CH:3]=[C:4]([C:6]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[O:7])[N:19]=1)[C:13]([NH2:15])=[NH:14]

참가 물질

4

반응물 2

HCID 178419747HCID 178419747, 화합물HCID 178513045HCID 178513045, 화합물

생성물 1

HCID 178419718HCID 178419718, 화합물수율 60%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 0.38 g (1.4 mmol) of 2-bromo-1-(4-imidazoyl)ethanone hydrobromide in 10 ml of acetone was warmed until homogeneous, then 0.17 g (1.4 mmol) of amidinothiourea was added and the mixture was heated at reflux for 0.5 hour. The mixture was cooled and the white precipitate was collected, washed with ether, and dried, thereby affording 0.24 g (60%) of 2-guanidino-4-(4-imidazoyl)thiazole hydrobromide, mp 225° (dec). nmr (DMSO-d6) (δ): 8.20 (s, 1H); 8.0 (b, 4H); 7.77 (s, 1H); 7.36 (s, 1H); high resolution mass spectrum: calcd. C7H8N6S: for 208.0531; found: 208.0517; calcd. for C7H8N6S.HBr.H2O: C, 27.37; H, 3.60; N, 27.36; found: C, 27.23; H, 3.57; N, 27.64.

후처리

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureat reflux for 0.5 hour
  4. temperatureThe mixture was cooled
  5. customthe white precipitate was collected
  6. washwashed with ether
  7. customdried

출처 및 근거

ORD 기록
ord-922d650cb64241289e428f4eb9116d5a
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04590299

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