HCID 178419747, 화합물 → HCID 178419718, 화합물
반응식
Br.[Br:2][CH2:3][C:4]([C:6]([C:8]1[N:9]=[CH:10][NH:11][CH:12]=1)=[O:7])=O.[C:13]([NH:16][C:17]([NH2:19])=[S:18])(=[NH:15])[NH2:14]>CC(C)=O>[BrH:2].[NH:16]([C:17]1[S:18][CH:3]=[C:4]([C:6]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[O:7])[N:19]=1)[C:13]([NH2:15])=[NH:14]참가 물질
4
실험 절차
A mixture of 0.38 g (1.4 mmol) of 2-bromo-1-(4-imidazoyl)ethanone hydrobromide in 10 ml of acetone was warmed until homogeneous, then 0.17 g (1.4 mmol) of amidinothiourea was added and the mixture was heated at reflux for 0.5 hour. The mixture was cooled and the white precipitate was collected, washed with ether, and dried, thereby affording 0.24 g (60%) of 2-guanidino-4-(4-imidazoyl)thiazole hydrobromide, mp 225° (dec). nmr (DMSO-d6) (δ): 8.20 (s, 1H); 8.0 (b, 4H); 7.77 (s, 1H); 7.36 (s, 1H); high resolution mass spectrum: calcd. C7H8N6S: for 208.0531; found: 208.0517; calcd. for C7H8N6S.HBr.H2O: C, 27.37; H, 3.60; N, 27.36; found: C, 27.23; H, 3.57; N, 27.64.