Tetrahydrofuran → HCID 178467483, 화합물

반응식

C([N:4]1[CH:8]=[C:7]([CH3:9])[N:6]=[CH:5]1)(=O)C.[O:10]1CC[CH2:12][CH2:11]1>>[C:11]([C:8]1[NH:4][CH:5]=[N:6][C:7]=1[CH3:9])(=[O:10])[CH3:12]

참가 물질

반응물 2

HCID 8028Tetrahydrofuran

HCID 109534921-Acetyl-4-methylimidazole

생성물 1

HCID 178467483HCID 178467483, 화합물수율 38%

실험 절차

A solution of 5.0 g (40.3 mmol) of 1-acetyl-4-methylimidazole in 700 ml of dry tetrahydrofuran was photolyzed in a quartz flask with a short wave ultraviolet light source (254 nm) for 24 hours. The tetrahydrofuran solution was concentrated in vacuo to give an oil which was chromatographed on silica gel using 5% methanol in chloroform as eluent to give 1.91 g (38%) of 5-acetyl-4-methylimidazole as a white solid, mp 140°-142°. nmr (CDCl3 /D6DMSO) (δ): 7.45 (s, 1H); 2.52 (s, 3H); 2.48 (s, 3H).

후처리

concentrationThe tetrahydrofuran solution was concentrated in vacuo
customto give an oil which
customwas chromatographed on silica gel using 5% methanol in chloroform as eluent

출처 및 근거

ORD 기록: ord-bca22a412c1d487ba3d9f14805accf3d
출처 데이터셋: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04590299

반응 노트

불러오는 중…