1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → dibenzylphosphoryl-L-alanyl-L-prolyl-L-alanine benzylester

https://huagongshe.com/ko/reaction/280772

참여 물질

역할	이름	HCID	투입량
반응물	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
반응물	1-Hydroxybenzotriazole	HCID 75771	—
반응물	L-Alanine, phenylmethyl ester, 4-methylbenzenesulfonate (1:1)	HCID 2802424	—
반응물	Dibenzylphosphory-L-alanyl-L-proline	HCID 53804723	—
용매	Dimethylformamide	HCID 6228	—
용매	Ethyl Acetate	HCID 8857	—
생성물	dibenzylphosphoryl-L-alanyl-L-prolyl-L-alanine benzylester	HCID 70042716	—

반응 조건

온도	-15 °C

반응 단계

Dibenzylphosphoryl-L-alanyl-L-proline (1.4 g, 3.2 m mole), 1-hydroxybenzotriazol (476 mg, 3.5 m mole) and L-alanine benzylester p-toluene sulfonate (1.3 g, 3.5 m mole) were dissolved in DMF (5 ml), and WSC (0.64 ml) was added thereto while cooling to -15° C. The reaction was continued for 3 hours under cooling and then overnight at room temperature, and ethyl acetate (100 ml) was added thereto. The mixture was washed with 1N hydrochloric acid, 5% sodium bicarbonate and water in order, and dried with anhydrous sodium sulfate. The thus obtained solution was distilled under reduced pressure leaving an oily dibenzylphosphoryl-L-alanyl-L-prolyl-L-alanine benzylester material.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US04590178
출처 데이터셋	uspto-grants-1986_05
ORD ID	ord-a4c3ab92871b4c02842e77e42db11aec
출처 메모	uspto-grants-1986_05