Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 280774생성일: 2026년 10월 23일
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → dibenzylphosphoryl-L-alanyl-L-prolyl-D-proline benzylester
https://huagongshe.com/ko/reaction/280774
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | benzyl (2R)-pyrrolidine-2-carboxylate hydrochloride | HCID 22827650 | — |
| 반응물 | Dibenzylphosphory-L-alanyl-L-proline | HCID 53804723 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | dibenzylphosphoryl-L-alanyl-L-prolyl-D-proline benzylester | HCID 70042657 | — |
반응 단계
Dibenzylphosphoryl-L-alanyl-L-proline (1.4 g, 3.2 m mole), HOBt (476 mg, 3.5 m mole) and oily D-proline benzylester hydrochloride (968 mg, 4 m mole) were dissolved in DMF (5 ml) and WSC (0.64 ml, 3.5 m mole) were added thereto while cooling to -15° C. The reaction was carried out for 3 hours under cooling and then overnight at room temperature, and ethyl acetate (100 ml) was added to the reaction solution. The mixture was washed with 1N hydrochloric acid, 5% sodium bicarbonate and water in order, and then dried with anhydrous sodium sulfate. The solution was distilled under reduced pressure leaving an oily dibenzylphosphoryl-L-alanyl-L-prolyl-D-proline benzylester material.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04590178 |
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| 출처 데이터셋 | uspto-grants-1986_05 |
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| ORD ID | ord-3452023ed2a042ba9e7ec69e15291341 |
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| 출처 메모 | uspto-grants-1986_05 |
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