Water → 1-(3-Furyl)-1-(4-methyl-5-thiazolyl)ethanol

HRID 2808

반응식

HRID 2808 반응식
Br[C:2]1[CH:6]=[CH:5][O:4][CH:3]=1.C([Li])CCC.[C:12]([C:15]1[S:19][CH:18]=[N:17][C:16]=1[CH3:20])(=[O:14])[CH3:13].O>C(OCC)C>[O:4]1[CH:5]=[CH:6][C:2]([C:12]([C:15]2[S:19][CH:18]=[N:17][C:16]=2[CH3:20])([OH:14])[CH3:13])=[CH:3]1

참가 물질

6

반응물 4

HCID 962WaterHCID 891643-BromofuranHCID 1622925-Acetyl-4-methylthiazoleHCID 178418339Butyllithium

생성물 1

HCID 189363091-(3-Furyl)-1-(4-methyl-5-thiazolyl)ethanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

실험 절차

3-Bromofuran (6.8 g) in diethylether (15 ml) was added dropwise to n-butyllithium (2.5M solution in hexane, 18.4 ml) in diethylether (20 ml) at -70° C. under a nitrogen atmosphere. After 1 hour, 5-acetyl-4-methylthiazole (5 g) in diethylether (15 ml) was added dropwise. After a further 3 hours at -70° C., the mixture was allowed to warm to room temperature and was then left overnight. The mixture was poured into water and extracted with diethylether. The product thus obtained was crystallised from diethylether, m.p. 102°-104° C.

후처리

  1. waitAfter a further 3 hours at -70° C.
  2. waitwas then left overnight
  3. extractionextracted with diethylether
  4. customThe product thus obtained
  5. customwas crystallised from diethylether, m.p. 102°-104° C.

출처 및 근거

ORD 기록
ord-ebc0a62248e849b8b300ac6d76abcd18
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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