2,6-Dimethyl-4-aminopyrimidine → HCID 13176760, 화합물

HRID 280811

반응식

HRID 280811 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][O:11][C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20]([N:23]=[C:24]=[O:25])(=[O:22])=[O:21])=[O:13]>C(#N)C>[CH3:9][C:4]1[N:3]=[C:2]([NH:1][C:24]([NH:23][S:20]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[C:12]([O:11][CH3:10])=[O:13])(=[O:22])=[O:21])=[O:25])[CH:7]=[C:6]([CH3:8])[N:5]=1

참가 물질

4

반응물 2

HCID 680392,6-Dimethyl-4-aminopyrimidineHCID 156281Benzoic acid, 2-(isocyanatosulfonyl)-, methyl ester

생성물 1

HCID 13176760HCID 13176760, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a suspension of 1.2 g of 4-amino-2,6-dimethylpyrimidine in 30 ml of dry acetonitrile with stirring was added 2.4 g of 2-methoxycarbonylbenzenesulfonylisocyanate. The mixture was stirred for two hours at ambient temperature, allowed to stand for sixteen hours and the desired product, which had precipitated, was removed by filtration and washed with butyl chloride to yield 2.4 g, m.p. 125°-127°. The product showed absorption peaks by Nuclear Magnetic Resource at 4.0, 2.62 and 2.9 ppm; consistent for the product.

후처리

  1. stirringThe mixture was stirred for two hours at ambient temperature
  2. waitto stand for sixteen hours
  3. customthe desired product, which had precipitated
  4. customwas removed by filtration
  5. washwashed with butyl chloride
  6. customto yield 2.4 g, m.p. 125°-127°
  7. customabsorption peaks by Nuclear Magnetic Resource at 4.0, 2.62 and 2.9 ppm

출처 및 근거

ORD 기록
ord-5735051ee7314864b53c38f2ea089f2f
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04591378

연결된 노트

불러오는 중…