Methanol → Salicylic acid, 4-nitro-, methyl ester

HRID 280832

반응식

HRID 280832 반응식
[OH:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:14]O>S(=O)(=O)(O)O>[OH:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:14])=[O:5]

참가 물질

4

반응물 2

HCID 887MethanolHCID 692664-Nitrosalicylic acid

생성물 1

HCID 139539Salicylic acid, 4-nitro-, methyl ester

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

2-hydroxy-4-nitrobenzoic acid (25 g) was dissolved in 100 ml of methanol and sulfuric acid (11 ml, density 1.84). The solution was boiled for 24 hrs, whereupon it was poured onto ice water and extracted with chloroform. The chloroform phase was shaken against sodium hydrogen carbonate solution, dried with magnesium sulfate and evaporated. The product was crystallized from methanol. Yield: 21 g.

후처리

  1. additionwas poured onto ice water
  2. extractionextracted with chloroform
  3. dry with materialdried with magnesium sulfate
  4. customevaporated
  5. customThe product was crystallized from methanol

출처 및 근거

ORD 기록
ord-5703b5d6de4b4f1faa1fd8a3a014c4fe
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04591584

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