Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1-Dichloroethane → 2,4-Dichlorobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1-Dichloroethane | HCID 6365 | — |
| 반응물 | 4-Chloro-2-nitrobenzonitrile | HCID 96924 | — |
| 반응물 | Lithium Chloride | HCID 433294 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 2,4-Dichlorobenzonitrile | HCID 81050 | 79.2% |
반응 단계
4.55 parts of 4-chloro-2-nitrobenzonitrile, 0.42 parts of lithium chloride, 1.11 parts of anhydrous aluminum chloride and 15 parts of N-methyl-2-pyrrolidone were reacted at 180° C. for 3 hours after the pattern of EXAMPLE B1. The reaction solution was added with 100 parts of dichloroethane, agitated for 30 minutes and filtered. Dichloroethane was distilled off from the filtrate and the residue was added with water to precipitate the crude crystals. The crude crystals were recrystallized by using a water-methanol mixed solvent to obtain 3.4 parts of 2,4-dichlorobenzonitrile with purity of 99%. Yield: 79.2%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04225534 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-402a1150f9fe498699052d6d9e667ac6 |
| 출처 메모 | uspto-grants-1980_09 |