Cyanoacetic acid hydrazide → 2-Formyl-3-methylquinoxaline-1,4-dioxide cyanoacetylhydrazone

HRID 28112

반응식

HRID 28112 반응식
[CH:1]([C:3]1[C:12]([CH3:13])=[N+:11]([O-:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[O-:15])=O.[C:16]([CH2:18][C:19]([NH:21][NH2:22])=[O:20])#[N:17]>C(O)C>[C:16]([CH2:18][C:19]([NH:21][N:22]=[CH:1][C:3]1[C:12]([CH3:13])=[N+:11]([O-:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[O-:15])=[O:20])#[N:17]

참가 물질

4

반응물 2

HCID 8820Cyanoacetic acid hydrazideHCID 178429580HCID 178429580, 화합물

생성물 1

HCID 1363356282-Formyl-3-methylquinoxaline-1,4-dioxide cyanoacetylhydrazone

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension comprising 20.4 grams (0.1 mole) of 2-formyl-3-methylquinoxaline-1,4-dioxide (m.p. of 180°-182° C.) and 9.9 grams (0.1 mole) of cyanoacetylhydrazine in 200 ml of ethanol was stirred for 4 hours at room temperature. The separated product was sucked off and washed with ethanol, so yielding 22.2 grams (78% of theoretical) of crude material. Upon crystallization from dimethylformamide, yellow crystals melting at a temperature within the range of 255°-260° C. were obtained.

후처리

  1. washwashed with ethanol
  2. customso yielding 22.2 grams (78% of theoretical) of crude material
  3. customUpon crystallization from dimethylformamide, yellow crystals
  4. custommelting at a temperature within the range of 255°-260° C.
  5. customwere obtained

출처 및 근거

ORD 기록
ord-ef9eb593a3cb44209c26cba25235065f
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225604

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