Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorophenol → 1-Methyl-2-(2-p-chlorophenoxyethyl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorophenol | HCID 4684 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-(2-Chloroethyl)-1-methylpiperidine | HCID 3016566 | — |
| 촉매 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Methyl-2-(2-p-chlorophenoxyethyl)-piperidine | HCID 23339173 | — |
반응 단계
200 ml of 50% aqueous sodium hydroxide solution and 1 g of triethylbenzylammonium chloride are added to a solution of 12.8 g of p-chlorophenol in 100 ml of CH2Cl2 ; 16.2 g of 1-methyl-2-(2-chloroethyl)-piperidine are added dropwise, while stirring; and the reaction mixture is stirred for a further one hour. After customary working up, 1-methyl-2-(2-p-chlorophenoxyethyl)-piperidine is obtained. Hydrochloride, m.p. 139°-140°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04225608 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-2812348ef1c64c43accd809c79458783 |
| 출처 메모 | uspto-grants-1980_09 |