Potassium Hydroxide → N-(Piperidin-4-yl)pyridin-2-amine

HRID 28131노트

반응식

HRID 28131 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][CH:8]1[CH2:13][CH2:12][N:11](C(OCC)=O)[CH2:10][CH2:9]1.[OH-].[K+]>CC(O)C>[NH:11]1[CH2:12][CH2:13][CH:8]([NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:9][CH2:10]1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 11357119Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate

생성물 1

HCID 21912674N-(Piperidin-4-yl)pyridin-2-amine

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 90 parts of ethyl 4-(2-pyridinylamino)-1-piperidinecarboxylate, 90 parts of potassium hydroxide and 720 parts of 2-propanol is stirred and refluxed for 2 days. The reaction mixture is evaporated. 1000 Parts of water are added to the residue and the product is extracted with dichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 13 parts of N-(4-piperidinyl)-2-pyridinamine.

후처리

  1. temperaturerefluxed for 2 days
  2. customThe reaction mixture is evaporated
  3. addition1000 Parts of water are added to the residue
  4. extractionthe product is extracted with dichloromethane
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue is crystallized from 2,2'-oxybispropane

출처 및 근거

ORD 기록
ord-5de2252d3ef44a7e9f19d928761cf090
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225606

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