Allyl bromide → HCID 23339063, 화합물

HRID 28148

반응식

HRID 28148 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.Br[CH2:25][CH:26]=[CH2:27]>C1C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:27][CH:26]=[CH2:25])[CH2:20][CH2:19]2)[C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 7841Allyl bromideHCID 162188N-(4-Chlorophenyl)-N-4-piperidinylbenzeneacetamide

생성물 1

HCID 23339063HCID 23339063, 화합물

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a stirring solution of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide, 3.8 parts of N-N-diethylethanamine in 200 parts of benzene are added portionwise 5 parts of 3-bromo-1-propene. After the addition is complete, the whole is heated for 21 hours at a temperature between 50°-60° C. The reaction mixture is cooled and filtered. The filtrate is washed successively with water, sodium hydrogen carbonate solution and water, dried over potassium carbonate and evaporated. The oily residue is converted into the hydrochloride salt in 1,1'-oxybisethane and 2-propanone, yielding 4 parts of N-(4-chlorophenyl)-N-[1-(2-propenyl)-4-piperidinyl]benzeneacetamide hydrochloride; mp. 225.5° C.

후처리

  1. additionAfter the addition
  2. temperaturethe whole is heated for 21 hours at a temperature between 50°-60° C
  3. temperatureThe reaction mixture is cooled
  4. filtrationfiltered
  5. washThe filtrate is washed successively with water, sodium hydrogen carbonate solution and water
  6. dry with materialdried over potassium carbonate
  7. customevaporated

출처 및 근거

ORD 기록
ord-13f2a08e8f854d1fbf80096f4777ac60
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225606

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