Triethylamine → N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride

HRID 28151

반응식

HRID 28151 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.C(N(CC)CC)C.I[CH2:32][CH2:33][CH3:34]>C1C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:32][CH2:33][CH3:34])[CH2:20][CH2:19]2)[C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 336431-Iodopropane2회HCID 162188N-(4-Chlorophenyl)-N-4-piperidinylbenzeneacetamide

생성물 1

HCID 23339041N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a stirred solution of 4 parts of N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide and 3 parts of N,N-diethylethanamine in 200 parts of benzene are added portionwise 4 parts of 1-iodopropane and the whole is stirred and refluxed for 47 hours. Then the second portion of 4 parts of 1-iodopropane is added and stirring and refluxing is continued for another 20 h.20. The reaction mixture is cooled and filtered. The filtrate is washed with water, dried and evaporated in vacuo. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane. The precipitated solid salt is filtered off and dried, yielding 3.5 parts of N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride; mp. 233.5° C.

후처리

  1. temperaturerefluxed for 47 hours
  2. stirringstirring
  3. temperaturerefluxing
  4. temperatureThe reaction mixture is cooled
  5. filtrationfiltered
  6. washThe filtrate is washed with water
  7. customdried
  8. customevaporated in vacuo
  9. filtrationThe precipitated solid salt is filtered off
  10. customdried

출처 및 근거

ORD 기록
ord-e2192b2ec0f648c4994e1497b6c9c192
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225606

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