Potassium Iodide → Ethyl 2-(p-chlorobenzylthio)-propionate
반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][SH:7])=[CH:4][CH:3]=1.Br[CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:7][CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:4][CH:3]=1참가 물질
6
실험 절차
A mixture of 19.5 ml (0.15 mol) of 4-chlorobenzylmercaptan, 27.1 g (0.15 mol) of ethyl α-bromopropionate, 21 g of potassium carbonate and 0.1 g of potassium iodide in 100 ml of anhydrous acetone is kept under reflux for 6 hrs. It is filtered, the precipitate is washed with acetone and the filtrate is evaporated in vacuo. 200 ml of ether are added to the residue and the mixture is washed with dilute NaOH, dilute HCl and water, dried and evaporated in vacuo.
후처리
- temperatureunder reflux for 6 hrs
- filtrationIt is filtered
- washthe precipitate is washed with acetone
- customthe filtrate is evaporated in vacuo
- addition200 ml of ether are added to the residue
- washthe mixture is washed with dilute NaOH, dilute HCl and water
- customdried
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-79fdbedb1756458194ee5fb490ea8b67
- 출처 데이터셋
- uspto-grants-1980_09
- 특허 번호
- US04225617
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