Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoic Acid → Ethyl 4-(4-bromobutyl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoic Acid | HCID 243 | — |
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Acetophenone | HCID 7410 | — |
| 반응물 | 1-Bromo-4-phenylbutane | HCID 259668 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | Sodium hypobromite | HCID 23673712 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 4-(4-bromobutyl)benzoate | HCID 12748303 | — |
반응 단계
In this case, 4-bromobutylbenzene is acylated with acetyl chloride and aluminum chloride; the resulting acetophenone is oxidized with sodium hypobromite to the benzoic acid, and this compound is esterified with ethanol and mineral acid to afford ethyl 4-(4-bromobutyl)benzoate. This ester is treated with the anion prepared from methyl methylthiomethyl sulfoxide and a strong base such as sodium hydride. The resulting dimethylmercaptal S-oxide is hydrolyzed with acid catalysis to the aldehyde intermediate XXI.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04225609 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-04f7284969114f2aaacaa2468f3dce4b |
| 출처 메모 | uspto-grants-1980_09 |