Methanol → 1-O-benzyl 2-O-methyl 4-(2,2-difluoroethoxy)pyrrolidine-1,2-dicarboxylate

반응식

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:21](=[O:22])[OH:23])[CH2:13][CH:14]([O:16][CH2:17][CH:18]([F:19])[F:20])[CH2:15]1.[CH3:31][OH:32].[Si:24]([CH3:25])([CH:26]=[N+:27]=[N-:28])([CH3:29])[CH3:30]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:21](=[O:22])[O:23][CH3:25])[CH2:13][CH:14]([O:16][CH2:17][CH:18]([F:19])[F:20])[CH2:15]1

참가 물질

반응물 3

HCID 887Methanol

HCID 167693Trimethylsilyldiazomethane

HCID 722986444-(2,2-Difluoroethoxy)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid

생성물 1

HCID 722986081-O-benzyl 2-O-methyl 4-(2,2-difluoroethoxy)pyrrolidine-1,2-dicarboxylate

출처 및 근거

ORD 기록: ord-eb508705ef4647319d0d82200ee5877c
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

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