Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-(2-Nitro-3-pyridinyl)-4-carbobenzoxypiperazine-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Fluoro-2-nitropyridine | HCID 2762802 | — |
| 반응물 | 4-((Benzyloxy)carbonyl)piperazine-2-carboxylic acid hydrochloride | HCID 45072677 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 1-(2-Nitro-3-pyridinyl)-4-carbobenzoxypiperazine-2-carboxylic acid | HCID 23339763 | — |
반응 단계
A mixture of 2.8 g. of 2-nitro-3-fluoropyridine, 5.0 g. of 4-carbobenzoxypiperazine-2-carboxylic acid, hydrochloride, 25 ml. of triethylamine, and 90 ml. of dimethyl sulfoxide is heated at 55° with stirring for 11/2 hours, then allowed to stand at room temperature overnight. A similar workup to that described in Example 1 gives 4.5 g. of the title product as a viscous orange glass. Thin layer chromatographic analysis of this material shows one single spot.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04225713 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-b065c219fde744c78b1c93192600a75d |
| 출처 메모 | uspto-grants-1980_09 |