Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Hydroxy-3-nitro-5-trifluoromethylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-chloro-3-nitro-5-(trifluoromethyl)benzoic Acid | HCID 10084457 | — |
| 촉매 | Tetraethylammonium Chloride | HCID 5946 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Hydroxy-3-nitro-5-trifluoromethylbenzoic acid | HCID 23339952 | — |
반응 단계
27 g of 2-chloro-3-nitro-5-trifluoromethyl-benzoic acid and 1 g of tetraethylammonium chloride are initially introduced into 200 ml of methanol, and 70 g of 50% strength sodium hydroxide solution are added dropwise, whilst stirring. The mixture is subsequently stirred at 65° C. for 5 hours, diluted with 300 ml of H2O and then rendered acid with hydrochloric acid. The solid product is filtered off and recrystallised from water. 16 g of 2-hydroxy-3-nitro-5-trifluoromethylbenzoic acid with the melting point: 166° to 168° C. are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04225731 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-fd2f6a8cbede49f6b17762a83d57156c |
| 출처 메모 | uspto-grants-1980_09 |