참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-Chloro-5-nitrobenzotrifluoride | HCID 61213 | — |
| 촉매 | Tetraethylammonium Chloride | HCID 5946 | — |
| 생성물 | 4-Nitro-2-(trifluoromethyl)anisole | HCID 69562 | 60.7% |
반응 단계
45 g of sodium hydroxide and 10 g of tetraethylammonium chloride in 200 g of methanol are initially introduced, 112.5 g of 2-chloro-5-nitro-benzotrifluoride are added dropwise at 25° to 30° C. and the mixture is then stirred at 30° C. for a further 5 hours. The mixture is then poured into 250 ml of water and extracted with methylene chloride. After evaporating off the solvent, the compound is recrystallised from isopropanol. 67 g of 2-methoxy-5-nitro-benzotrifluoride with a melting point of 70° to 74° C. are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04225731 |
|---|
| 출처 데이터셋 | uspto-grants-1980_09 |
|---|
| ORD ID | ord-ce9d6417b525447fad8a7a50888eda11 |
|---|
| 출처 메모 | uspto-grants-1980_09 |
|---|
